The Cornell iGEM Project Team is an award-winning synthetic biology research team of 50 undergraduate students. The team comprises five subteams: Wet Lab, Product Development, Policy and Practices, Business, and Wiki/Design. The team works throughout the school year and summer to solve local and global problems related to medical applications, environmental concerns, and human and animal health. We compete against 300+ multidisciplinary teams from all around the world at the iGEM Grand Jamboree, hosted annually by the International Genetically Engineered Machine (iGEM) Foundation.
Synthetic biology is the field in which scientists redesign and repurpose machinery naturally found in the biological world to achieve a man-driven goal. Some famous examples of synthetic biology that have changed the world as we know it:
The Grand Jamboree is the annual competition hosted by the iGEM foundation during which hundreds of teams from around the globe gather to present their projects, network with other teams and companies, and learn more about the field of synthetic biology. It is made up of multiple different events spanning the course of four days. Everything is bookended by the opening and closing ceremonies. In between these ceremonies, some activities you might find are project presentation sessions, poster sessions and workshops, along with other special events such as a career fair or a start-up showcase. In addition to participating in these activities and speaking with other teams, you also get the chance to meet representatives from sponsor companies and talk with them as well.
The Grand Jamboree means a lot to iGEM, but not just for the reason that it is our chance to show off our impressive work that we do annually. The Grand Jamboree is also a tremendous opportunity for team bonding and camaraderie. Each year after the Grand Jamboree ends and iGEM members head back from Paris to Ithaca, everyone leaves feeling as if they have gotten closer to the people around them.
Wet Lab designs and creates all biological products for iGEM through genetic circuit design and synthetic biology lab techniques. Through cloning and transformation, we genetically engineer bacteria to produce proteins and perform actions that bacteria would not normally do to solve problems locally and nationally. Wet Lab also plays an essential role in testing, modeling, and presenting the project. The robust biological framework that Wet Lab develops integrates with developments from all other subteams involved in iGEM as the entire team works to create a cohesive project.
This year, we are working with yeast and using their metabolic pathways to produce ursolic acid (UA), an anticancer drug. After purifying the UA, we will encapsulate them into lipid nanoparticles to aid drug delivery for specific targets.
In previous years, some examples of wet lab projects have been engineering E. coli to detect and degrade toxins from algae (2019), creating a bacteriotherapy treatment and tracking system for cancerous malignant tumors (2020), editing bacteria to produce colorful bio-ink while uptaking carbon dioxide (2022), and more!